Effect of hydrogen on nitric oxide and its synthase in hippocampus tissue of rats following acute cerebral ischemia/reperfusion injury
- Disease Model：Cerebral ischemia and reperfusion
- Corresponding Author：冯国营(Guoying Feng)
- Corresponding Unit：Foundation College of Binzhou Medical University
- Experimental Subject：Rats
- Way of Hydrogen Administration：Saturated hydrogen saline, intraperitoneal injection
- Dosage：10 ml/kg
- Duration：Single Test
After 6 hours of treatment, NOS positive cells in the hippocampus, NO content and NOS activity of model group are higher than those of sham-operation group while these indicators of treatment group decline compared with model group. After 24 hours of treatment, NOS positive cells in the hippocampus, NO content and NOS activity of model group are higher than those of sham-operation group, and the difference has statistic significance. The difference between treatment group and model group has no statistic significance.
Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.