Consumption of hydrogen-rich water alleviates renal injury in spontaneous hypertensive rats
- Journal：Molecular and Cellular Biochemistry
- Disease Model：Hypertension
- Corresponding Author：Xiaohui Miao
- Corresponding Unit：Changzheng Hospital, Second Military Medical University
- Experimental Subject：Rats
- Way of Hydrogen Administration：Hydrogen rich water, oral
- Dosage：1.3 + 0.2 mg/L
- Duration：In March
Hydrogen-rich water has no effect on blood pressure of hypertensive rats but can lessen kidney injury. Hydrogen-rich water can reduce generation of active hydrogen, up-regulate SOD, glutathione peroxidase, glutathione -S- epoxide transferase and catalase activity, and suppress NADPH oxidase activity. Hydrogen-rich water can suppress expression of proinflammatory cytokine including TNF-α, IL-6, IL-1β and macrophage chemotactic factor 1. Hydrogen-rich water can also protect mitochondria function including formation of adenosine triphosphate and membrane integrity.
Molecular hydrogen is the smallest molecule known in nature, and it was regarded by the scientific community as the inert gas without biological effects. In 2007, Nature Medicine published a paper confirming that hydrogen inhalation can protect cerebral ischemia-reperfusion injury. As of now, nearly 1200 relevant papers have been published internationally confirming the biological effects of hydrogen, and involving 63 kinds of important human diseases.